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Therefore, the metabolite is accountable for about 20% of sildenafil's motion. Sildenafil is excreted as metabolites predominantly during the feces (about eighty% of administered oral dose) also to a lesser extent in the urine (all around 13% from the administered oral dose). If taken with a superior-Body fat meal, absorption is decreased; some time taken to succeed in the most plasma focus boosts by all over 1 hour, and the most focus alone is lessened by almost a person-third.[fifty two]
Chiedere in ogni caso informazioni al proprio medico sulla eventuale possibilità di assumere il tadalafil se si è in trattamento ipotensivo, anche con farmaci diversi dai nitrati.
Tadalafil (20 mg) è stato studiato in associazione a four classi di antipertensivi. Nei soggetti che assumevano più antipertensivi, le variazioni della pressione sanguigna controllata ambulatorialmente apparivano correlabili al grado di controllo della pressione sanguigna. Nei soggetti con pressione sanguigna ben controllata, la riduzione della pressione sanguigna period minima e simile a quella osservata nei soggetti sani.
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